Verlag des Forschungszentrums Jülich
JUEL-2881
Patt, Jörg Thomas
Katalytische Konversion von 11CO2 und 11CO zu Synthesevorläufern für C-Markierungen
136 S., 1994
The positron emitter carbon-11 (T1/2 =20.3 min) is an ideal radio nuclide for tracers
in positron emission tomography (PET). In this study catalytic methods for the
synthesis of 111Cjalcohols have been investigated.
The formation of C1Cjmethanoi has been studied on PdlAI20 3 and CulZnO/AI20 3
catalysts with respect to CO and CO2 carrier addition to the synthesis gas. Carbon
monoxide was identified as the precursor of methanol formation on the PdlAl20 3catalyst.
In contrast on the CulZnO/Al20 3-catalyst methanol was formed on a
reaction pathway via an adsorbed CO2-species. A n.c.a.-[l1Cjmethanol synthesis
basing on the CulZnO/Al20 3-catalyst has been developed by substitution of the
oxygen containing components CO and CO2 in the synthesis gas by N20 . The
radiochemical yield, the low selectivity of 111Cjmethanoi production and the rather
slow kinetics of this process were arguments against the practical use of this
process in the synthesis of llC-Iabelling agents.
A new method for the n.c.a.-synthesis of higher 111Cjaicohois using Wilkinson's
catalyst IP(CsHshhRhCI is described. The product of the reaction of "co and
IP(CsHshhRhCI, n.c.a.-trans-[P(CsHshhRhelCO)CI, is reacted with alkyliodide and
M+[B(ORhHf yielding the C1Cjaicohoi in high specific activity and high
radiochemical yield.
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